WHO International Chemical Reference Substances (ICRS) are primary chemical reference substances established and maintained by the World Health Organization (WHO). They serve worldwide as authoritative standards for the quality control of pharmaceutical substances and preparations.

WHO International Standards for Antibiotics (ISA) are global reference standards established by the World Health Organization (WHO). They serve as worldwide benchmarks for comparison and quality control of antibiotics.
Since 2006, the responsibility for the production, storage and distribution of WHO standards has been with the EDQM (European Directorate for the Quality of Medicines & HealthCare).